Endocrine Abstracts

Testicular adrenal rest tumors (TARTs) are benign masses causing testicular damage and infertility. Their development is attributed to chronic stimulation of elevated ACTH levels. Several diseases are characterized by an increase of ACTH, however TARTs have been described almost exclusively in patients with congenital adrenal hyperplasia (CAH), excluding only rare cases. X-linked adrenoleukodystrophy (X-ALD) is a rare cause of primary adrenal insufficiency (PAI). It is a genet...

Objective: Polycystic ovary syndrome (PCOS) phenotypes, generated by the possible combinations of the three Rotterdam diagnostic criteria, show a different scale of metabolic risk among PCOS women, being greatest in the classic subgroup, followed by the ovulatory and normoandrogenic phenotype. Aldosterone is an important cardiovascular risk factor. Previous studies reported increased levels of aldosterone in PCOS women, suggesting a possible role in the development of some car...

Context: Fludrocortisone (FC) is the mineralocorticoid (MC) replacement treatment for patients with primary adrenal insufficiency (PAI). Objective: To explore the dose of FC treatment and its relationship with glucocorticoid therapy, sodium, potassium, renin and clinical parameters. Design: Longitudinal study.Setting: Monocentric cohort.Patients: Data of 193 patients with PAI (130 autoi...

Background and aim: Aldosterone-to-Renin Ratio (ARR) is recommended as initial test to screen for Primary Aldosteronism (PA), especially in high-risk hypertensive population. Endocrine Society (ES) Guidelines recommend that patients with an increased ARR should undergo one or more confirmatory tests in order to confirm or exclude PA diagnosis. Captopril Challenge Test (CCT) and Saline Infusion Test (SIT) are commonly used in routine clinical practice. The aim of our study was ...

Introduction: Adrenal crisis (AC) is the most severe manifestation of adrenal insufficiency, still responsible for a high mortality of affected patients, especially with primary adrenal insufficiency (PAI). Its presentation is insidious, leading to a delayed diagnosis and treatment. Patient education is crucial in the prevention and self-management of AC.Aim of the study: We want to evaluate the incidence, features (symptoms, signs, laboratory findings),...

Introduction and aim: The purpose of replacement therapy in Adrenal Insufficiency (AI) is mimicking endogenous cortisol levels as closely as possible: dual release hydrocortisone (DR-HC) has been introduced to replicate the circadian cortisol rhythm. Multiple daily saliva collections could be used to assess the cortisol concentration during real-life: our aim was to study the salivary cortisol rhythm in AI.Materials and methods: We prospectively evaluate...

Beyond the huge impact on physical health, coronavirus disease-19 (COVID-19) epidemic represents a significant psychological stressor, causing effects on mental health. The psychological distress of the epidemic and consequent mass quarantine on patients with hypocortisolism, particularly frail and vulnerable to infections and stress, is unknown. The current multicentre, web-survey-based, case-control study evaluated the psychological impact of COVID-19 quarantine in a large c...